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. 2024 Aug 5;10(15):e35752. doi: 10.1016/j.heliyon.2024.e35752

Fig. 5.

Fig. 5

Evaluation of peripheral markers of glucose metabolism in 18-months-old control Tau-VLW mice (TC) and chronically (9 months) treated with metformin (TM). (A) Intraperitoneal glucose tolerance test on overnight fasted mice (IpGTT) and (B) Area under the curves. Blood glucose concentrations under basal conditions (time 0, before 2 g/kg BW glucose overload) as well as 15, 30, 60, 90, 120 and 150 min later. Values are expressed as means ± SEM (TC, n = 6; TM, n = 9). Significant differences when compared with time 0 within TC (ap<0.01) and, within TM (bp < 0.01) the trend to significance cp = 0.06 is also shown (one-way ANOVA followed by Dunnett's correction for comparisons with time 0). Significant differences between TC and TM mice in each time point are depicted as *p < 0.05, **p < 0.01 (two-way ANOVA followed by post-hoc Bonferroni correction). **p < 0.01, when compared area under the curves (Student's unpaired t-test). (C) Fasting plasma insulin concentrations and (D) HOMA-IR index. (TC, n = 3; TM, n = 4). (E) Cumulative body weight changes (% vs initial BW). (TC, n = 12, 12, 10 and 6 at 9, 11, 15 and 18-months-old mice, respectively; TM, n = 13, 12, 11 and 11, at 9, 11, 15 and 18-months-old mice, respectively). All values are expressed as means ± SEM. #p = 0.06 (Student's unpaired t-test).