Table 3.
Statistical analysis of SUV values of glucose metabolism measured by [18F]FDG-PET in selected brain areas.
| Age range (months-old) | VEHICLE (TC) |
METFORMIN (TM) |
||||
|---|---|---|---|---|---|---|
| 9 to 11 | 11 to 15 | 15 to 18 | 9 to 11 | 11 to 15 | 15 to 18 | |
| Cortex | Z = −1.10 (p = 0.272) | Z = −2.70 (p = 0.007*) | Z = −1.52 (p = 0.128) | Z = −1.06 (p = 0.289) | Z = −0.98 (p = 0.328) | Z = −2.14 (p = 0.033*) |
| Striatum | Z = −1.57 (p = 0.117) | Z = −2.55 (p = 0.011*) | Z = −1.52 (p = 0.128) | Z = −1.10 (p = 0.272) | Z = −0.71 (p = 0.477) | Z = −1.87 (p = 0.062) |
| Hippocampus | Z = −1.57 (p = 0.117) | Z = −2.80 (p = 0.005*) | Z = −1.35 (p = 0.176) | Z = −1.02 (p = 0.308) | Z = −0.89 (p = 0.374) | Z = −1.78 (p = 0.075) |
| Cerebellum | Z = −0.78 (p = 0.433) | Z = −2.81 (p = 0.005*) | Z = −0.17 (p = 0.866) | Z = −0.86 (p = 0.388) | Z = −1.33 (p = 0.182) | Z = −0.97 (p = 0.333) |
| Whole brain | Z = −1.57 (p = 0.117) | Z = −2.70 (p = 0.007*) | Z = −1.52 (p = 0.128) | Z = −0.94 (p = 0.346) | Z = −0.98 (p = 0.328) | Z = −1.60 (p = 0.109) |
| n | 12 | 10 | 7 | 12 | 11 | 11 |
Z score and p-values from the Wilcoxon signed-rank test performed for each pair of measurements within each brain region. Significant differences (*) are indicated.