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. Author manuscript; available in PMC: 2024 Aug 21.
Published in final edited form as: Arthritis Rheumatol. 2022 Nov 6;74(12):1971–1983. doi: 10.1002/art.42284

Figure 2: Attenuation of kidney damage, serum autoantibody levels, and human B cell responses by 4-OI.

Figure 2:

A) Representative immunofluorescence microphotographs displaying IC deposition (IgG red, C3 green, nuclei in blue); magnification 40x. B) Image J quantification depicting pixel analysis of glomeruli in 3 different images/mouse from panel A. C) Analysis of proteinuria at the time of euthanasia. Serum antibodies against D) RNP, and E) ds-DNA; mice were treated with 4-OI or vehicle control with n numbers indicated in the figure; the discrepancy in numbers is due to failure to collect urine in some of the mice in C. F) Human B cell proliferation after stimulation (BCI) or non-stimulation (NS) and G) total IgG secretion in 3 different healthy donors. Bar graphs represent mean ± SEM. The statistical analysis was done using Mann Whitney test *:p<0.05, **:p<0.01, ***:p<0.001.