Comparison 1. Doxazosin vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in trough SBP	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 2 mg	2	93	Mean Difference (IV, Fixed, 95% CI)	‐5.03 [‐10.71, 0.64]
1.2 4 mg	2	91	Mean Difference (IV, Fixed, 95% CI)	‐5.84 [‐11.44, ‐0.23]
1.3 8 mg	2	91	Mean Difference (IV, Fixed, 95% CI)	‐7.24 [‐12.93, ‐1.56]
1.4 12 mg	1	55	Mean Difference (IV, Fixed, 95% CI)	‐6.1 [‐15.27, 3.07]
2 Change in trough DBP	3		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 2 mg	2	93	Mean Difference (IV, Fixed, 95% CI)	‐3.01 [‐6.43, 0.42]
2.2 4 mg	3	326	Mean Difference (IV, Fixed, 95% CI)	‐3.36 [‐5.06, ‐1.66]
2.3 8 mg	2	90	Mean Difference (IV, Fixed, 95% CI)	‐4.13 [‐7.61, ‐0.65]
2.4 12 mg	1	56	Mean Difference (IV, Fixed, 95% CI)	‐3.8 [‐8.64, 1.04]
3 Change in peak SBP	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3.1 2 mg	1	44	Mean Difference (IV, Fixed, 95% CI)	‐6.8 [‐13.96, 0.36]
3.2 4 mg	1	35	Mean Difference (IV, Fixed, 95% CI)	‐6.0 [‐13.08, 1.08]
3.3 8 mg	1	35	Mean Difference (IV, Fixed, 95% CI)	‐12.90 [‐20.34, ‐5.46]
4 Change in peak DBP	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
4.1 2 mg	1	44	Mean Difference (IV, Fixed, 95% CI)	‐4.30 [‐8.92, 0.32]
4.2 4 mg	1	35	Mean Difference (IV, Fixed, 95% CI)	‐4.4 [‐9.02, 0.22]
4.3 8 mg	1	35	Mean Difference (IV, Fixed, 95% CI)	‐8.5 [‐13.32, ‐3.68]
5 Change in trough heart rate	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
5.1 2 mg	1	44	Mean Difference (IV, Fixed, 95% CI)	‐1.90 [‐6.62, 2.82]
5.2 4 mg	1	35	Mean Difference (IV, Fixed, 95% CI)	‐1.5 [‐6.22, 3.22]
5.3 8 mg	1	35	Mean Difference (IV, Fixed, 95% CI)	1.0 [‐4.67, 6.67]
6 Change in peak heart rate	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
6.1 2 mg	1	44	Mean Difference (IV, Fixed, 95% CI)	‐0.10 [‐4.82, 4.62]
6.2 4 mg	1	35	Mean Difference (IV, Fixed, 95% CI)	1.30 [‐3.42, 6.02]
6.3 8 mg	1	35	Mean Difference (IV, Fixed, 95% CI)	3.2 [‐2.47, 8.87]
7 Total withdrawals due to adverse effects	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
7.1 2‐8 mg	1	135	Risk Ratio (M‐H, Fixed, 95% CI)	1.94 [0.24, 15.54]
7.2 2‐12 mg	1	248	Risk Ratio (M‐H, Fixed, 95% CI)	2.71 [0.66, 11.13]