Comparison 2. Prazosin vs Placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in trough SBP	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 2.5 mg GITS	1	65	Mean Difference (IV, Fixed, 95% CI)	‐3.60 [‐11.86, 4.66]
1.2 3 mg	1	28	Mean Difference (IV, Fixed, 95% CI)	‐3.0 [‐13.88, 7.88]
1.3 10 mg GITS	1	72	Mean Difference (IV, Fixed, 95% CI)	‐9.20 [‐17.23, ‐1.17]
1.4 20 mg GITS	1	68	Mean Difference (IV, Fixed, 95% CI)	‐11.7 [‐20.17, ‐3.23]
2 Change in trough DBP	2		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
2.1 2.5 mg GITS	1	65	Mean Difference (IV, Fixed, 95% CI)	‐2.4 [‐6.54, 1.74]
2.2 3 mg	1	28	Mean Difference (IV, Fixed, 95% CI)	‐4.0 [‐8.00, 2.00]
2.3 10 mg GITS	1	72	Mean Difference (IV, Fixed, 95% CI)	‐6.80 [‐10.87, ‐2.73]
2.4 20 mg GITS	1	68	Mean Difference (IV, Fixed, 95% CI)	‐7.0 [‐11.11, ‐2.89]
3 Change in trough heart rate	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3.1 2.5 mg GITS	1	65	Mean Difference (IV, Fixed, 95% CI)	2.1 [‐2.53, 6.73]
3.2 10 mg GITS	1	72	Mean Difference (IV, Fixed, 95% CI)	1.80 [‐2.79, 6.39]
3.3 20 mg GITS	1	68	Mean Difference (IV, Fixed, 95% CI)	2.9 [‐1.69, 7.49]
4 Total withdrawals due to adverse effects	1		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 2.5‐20 mg GITS	1	220	Odds Ratio (M‐H, Fixed, 95% CI)	0.72 [0.21, 2.43]