Comparison 3. NSAIDs vs. placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Cognition:ADAScog all studies	9	1745	Mean Difference (IV, Random, 95% CI)	‐1.41 [‐3.13, 0.32]
1.1 traditional NSAIDs vs placebo	6	411	Mean Difference (IV, Random, 95% CI)	‐3.81 [‐7.94, 0.33]
1.2 Selective COX‐2 inhibitor	4	1334	Mean Difference (IV, Random, 95% CI)	0.30 [‐0.99, 1.60]
2 Cognition:MMSE all	6	1268	Mean Difference (IV, Random, 95% CI)	‐1.08 [‐2.21, 0.04]
2.1 traditional NSAIDs vs placebo	4	234	Mean Difference (IV, Random, 95% CI)	‐3.22 [‐6.58, 0.14]
2.2 Selective COX‐2 inhibitor	2	1034	Mean Difference (IV, Random, 95% CI)	0.34 [‐0.07, 0.76]
3 CIBIC+	3	1099	Mean Difference (IV, Fixed, 95% CI)	0.04 [‐0.09, 0.16]
3.1 traditional NSAIDs vs placebo	1	38	Mean Difference (IV, Fixed, 95% CI)	‐0.10 [‐0.58, 0.38]
3.2 Selective COX‐2 inhibitor	2	1061	Mean Difference (IV, Fixed, 95% CI)	0.05 [‐0.08, 0.18]
4 CDR sum score	3	1124	Mean Difference (IV, Fixed, 95% CI)	0.03 [‐0.25, 0.30]
4.1 traditional NSAIDs vs placebo	1	229	Mean Difference (IV, Fixed, 95% CI)	0.10 [‐0.50, 0.70]
4.2 Selective COX‐2 inhibitor	3	895	Mean Difference (IV, Fixed, 95% CI)	0.01 [‐0.30, 0.32]
5 NPI	3	632	Mean Difference (IV, Fixed, 95% CI)	0.81 [0.14, 1.49]
5.1 traditional NSAIDs vs placebo	3	399	Mean Difference (IV, Fixed, 95% CI)	0.84 [0.14, 1.54]
5.2 Selective COX‐2 inhibitor	1	233	Mean Difference (IV, Fixed, 95% CI)	0.40 [‐2.54, 3.34]
6 Mood/depression	1	40	Std. Mean Difference (IV, Random, 95% CI)	‐0.34 [‐0.96, 0.29]
6.1 selective COX‐2 inhibitor vs placebo	1	40	Std. Mean Difference (IV, Random, 95% CI)	‐0.34 [‐0.96, 0.29]
7 Clinical global impression: GDS	1	31	Std. Mean Difference (IV, Random, 95% CI)	‐0.43 [‐1.15, 0.29]
7.1 traditional NSAIDs vs placebo	1	31	Std. Mean Difference (IV, Random, 95% CI)	‐0.43 [‐1.15, 0.29]
8 Clinical global impression: CGIC and NOSGER 6 months	2	441	Std. Mean Difference (IV, Random, 95% CI)	‐0.07 [‐0.49, 0.35]
8.1 traditional NSAIDs vs placebo	1	31	Std. Mean Difference (IV, Random, 95% CI)	‐0.44 [‐1.16, 0.27]
8.2 Selective COX‐2 inhibitor	1	410	Std. Mean Difference (IV, Random, 95% CI)	0.05 [‐0.16, 0.26]
9 Behavioral disturbance	3	479	Std. Mean Difference (IV, Random, 95% CI)	0.09 [‐0.29, 0.46]
9.1 traditional NSAIDs vs placebo	2	69	Std. Mean Difference (IV, Random, 95% CI)	‐0.03 [‐0.89, 0.82]
9.2 Selective COX‐2 inhibitor	1	410	Std. Mean Difference (IV, Random, 95% CI)	0.16 [‐0.04, 0.37]
10 Activity of daily living	7	1737	Std. Mean Difference (IV, Random, 95% CI)	‐0.22 [‐0.48, 0.04]
10.1 traditional NSAIDs vs placebo	4	375	Std. Mean Difference (IV, Random, 95% CI)	‐0.48 [‐0.97, 0.01]
10.2 Selective COX‐2 inhibitor	4	1362	Std. Mean Difference (IV, Random, 95% CI)	‐0.03 [‐0.22, 0.17]
11 Quality of life	2	382	Std. Mean Difference (IV, Random, 95% CI)	0.08 [‐0.14, 0.29]
11.1 traditional NSAIDs vs placebo	2	205	Std. Mean Difference (IV, Random, 95% CI)	0.07 [‐0.22, 0.36]
11.2 Selective COX‐2 inhibitor	1	177	Std. Mean Difference (IV, Random, 95% CI)	0.09 [‐0.23, 0.41]
12 Caregiver burden	3	201	Std. Mean Difference (IV, Random, 95% CI)	‐0.35 [‐0.63, ‐0.07]
12.1 traditional NSAIDs vs placebo	3	201	Std. Mean Difference (IV, Random, 95% CI)	‐0.35 [‐0.63, ‐0.07]
13 Gastrointestinal side effects	9	1675	Risk Ratio (M‐H, Fixed, 95% CI)	1.94 [1.36, 2.77]
14 Elevated creatinine	2	92	Risk Ratio (M‐H, Fixed, 95% CI)	4.30 [0.54, 34.30]
15 Elevated liver function test	3	132	Risk Ratio (M‐H, Fixed, 95% CI)	4.27 [0.97, 18.76]
16 Headache	4	577	Risk Ratio (M‐H, Fixed, 95% CI)	1.08 [0.34, 3.44]
17 Psychiatric side effects	4	586	Risk Ratio (M‐H, Fixed, 95% CI)	1.11 [0.67, 1.86]
18 Bleeding	1	425	Risk Ratio (M‐H, Fixed, 95% CI)	3.45 [0.18, 66.35]
19 Heart disease	2	776	Risk Ratio (M‐H, Fixed, 95% CI)	7.58 [1.48, 38.90]
20 Cerebrovascular side effects	4	1555	Risk Ratio (M‐H, Fixed, 95% CI)	1.05 [0.54, 2.02]
21 Hypertension	2	402	Risk Ratio (M‐H, Fixed, 95% CI)	5.41 [1.36, 21.60]
22 Hyperglycemia	1	51	Risk Ratio (M‐H, Fixed, 95% CI)	1.92 [0.19, 19.90]
23 Rash	2	61	Risk Ratio (M‐H, Fixed, 95% CI)	3.47 [1.00, 12.04]
24 Respiratory side effects	1	461	Risk Ratio (M‐H, Fixed, 95% CI)	2.73 [0.61, 12.17]
25 Dry mouth	1	351	Risk Ratio (M‐H, Fixed, 95% CI)	3.24 [0.40, 26.00]
26 Fatigue	1	351	Risk Ratio (M‐H, Fixed, 95% CI)	2.31 [1.06, 5.04]
27 Dizziness	3	423	Risk Ratio (M‐H, Fixed, 95% CI)	2.40 [1.10, 5.25]
28 Abnormal labs other than Cr. and LFT	2	466	Risk Ratio (M‐H, Fixed, 95% CI)	1.34 [0.21, 8.69]
29 Withdrawal due to side effects	3	1083	Risk Ratio (M‐H, Fixed, 95% CI)	1.22 [0.89, 1.65]
30 Abdominal pain or dyspepsia	8	994	Risk Ratio (M‐H, Fixed, 95% CI)	1.76 [0.97, 3.22]
31 Constipation or diarrhea	3	527	Risk Ratio (M‐H, Fixed, 95% CI)	2.03 [0.84, 4.88]
32 Nausea or vomiting	3	112	Risk Ratio (M‐H, Fixed, 95% CI)	1.69 [0.39, 7.38]
33 Death	9	1711	Risk Ratio (M‐H, Fixed, 95% CI)	1.67 [0.85, 3.31]