Comparison 5. Selective COX‐2 inhibitor vs. placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Gastrointestinal side effects	5	1355	Risk Ratio (M‐H, Fixed, 95% CI)	2.03 [1.37, 3.03]
1.1 Selective COX‐2 inhibitor	5	1355	Risk Ratio (M‐H, Fixed, 95% CI)	2.03 [1.37, 3.03]
2 Hypertension	1	177	Risk Ratio (M‐H, Fixed, 95% CI)	8.65 [0.51, 146.03]
2.1 Selective COX‐2 inhibitor	1	177	Risk Ratio (M‐H, Fixed, 95% CI)	8.65 [0.51, 146.03]
3 Heart disease	2	602	Risk Ratio (M‐H, Fixed, 95% CI)	7.52 [1.47, 38.41]
3.1 Selective COX‐2 inhibitor	2	602	Risk Ratio (M‐H, Fixed, 95% CI)	7.52 [1.47, 38.41]
4 Rash	2	61	Risk Ratio (M‐H, Fixed, 95% CI)	3.47 [1.00, 12.04]
4.1 Selective COX‐2 inhibitor	2	61	Risk Ratio (M‐H, Fixed, 95% CI)	3.47 [1.00, 12.04]
5 Headache	2	482	Risk Ratio (M‐H, Fixed, 95% CI)	1.76 [0.35, 8.81]
5.1 Selective COX‐2 inhibitor	2	482	Risk Ratio (M‐H, Fixed, 95% CI)	1.76 [0.35, 8.81]
6 Psychiatric side effects	2	501	Risk Ratio (M‐H, Fixed, 95% CI)	1.53 [0.87, 2.69]
6.1 Selective COX‐2 inhibitor	2	501	Risk Ratio (M‐H, Fixed, 95% CI)	1.53 [0.87, 2.69]
7 Bleeding	1	425	Risk Ratio (M‐H, Fixed, 95% CI)	3.45 [0.18, 66.35]
7.1 Selective COX‐2 inhibitor	1	425	Risk Ratio (M‐H, Fixed, 95% CI)	3.45 [0.18, 66.35]
8 Cerebrovascular side effects	3	1330	Risk Ratio (M‐H, Fixed, 95% CI)	0.82 [0.40, 1.64]
8.1 Selective COX‐2 inhibitor	3	1330	Risk Ratio (M‐H, Fixed, 95% CI)	0.82 [0.40, 1.64]
9 Respiratory side effects	1	461	Risk Ratio (M‐H, Fixed, 95% CI)	2.73 [0.61, 12.17]
9.1 Selective COX‐2 inhibitor	1	461	Risk Ratio (M‐H, Fixed, 95% CI)	2.73 [0.61, 12.17]
10 Dry mouth	1	177	Risk Ratio (M‐H, Fixed, 95% CI)	1.37 [0.06, 33.01]
10.1 Selective COX‐2 inhibitor	1	177	Risk Ratio (M‐H, Fixed, 95% CI)	1.37 [0.06, 33.01]
11 Fatigue	1	177	Risk Ratio (M‐H, Fixed, 95% CI)	1.16 [0.51, 2.61]
11.1 Selective COX‐2 inhibitor	1	177	Risk Ratio (M‐H, Fixed, 95% CI)	1.16 [0.51, 2.61]
12 Dizziness	2	198	Risk Ratio (M‐H, Fixed, 95% CI)	1.26 [0.53, 3.01]
12.1 Selective COX‐2 inhibitor	2	198	Risk Ratio (M‐H, Fixed, 95% CI)	1.26 [0.53, 3.01]
13 Abnormal labs other than Cr. and LFT	1	425	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.09, 10.74]
13.1 Selective COX‐2 inhibitor	1	425	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.09, 10.74]
14 Death	5	1391	Risk Ratio (M‐H, Fixed, 95% CI)	1.88 [0.87, 4.03]
14.1 Selective COX‐2 inhibitor	5	1391	Risk Ratio (M‐H, Fixed, 95% CI)	1.88 [0.87, 4.03]
15 Withdrawal due to side effects	4	1370	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.71, 1.31]
15.1 Selective COX‐2 inhibitor	4	1370	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.71, 1.31]
16 Abdominal pain or dyspepsia	4	663	Risk Ratio (M‐H, Fixed, 95% CI)	1.67 [0.79, 3.55]
16.1 Selective COX‐2 inhibitor	4	663	Risk Ratio (M‐H, Fixed, 95% CI)	1.67 [0.79, 3.55]
17 Constipation or diarrhea	2	476	Risk Ratio (M‐H, Fixed, 95% CI)	3.16 [1.04, 9.66]
17.1 Selective COX‐2 inhibitor	2	476	Risk Ratio (M‐H, Fixed, 95% CI)	3.16 [1.04, 9.66]
18 Nausea or vomiting	2	61	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.16, 6.29]
18.1 Selective COX‐2 inhibitor	2	61	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.16, 6.29]
19 Abnormal liver function test	1	40	Risk Ratio (M‐H, Fixed, 95% CI)	4.52 [0.58, 35.33]