Hüll 1999.
| Methods | Double blind randomised controlled trial, 6 months | |
| Participants | 10 Participants (7 intervention, 3 control) who had AD diagnosis, unclear if they were out‐patient or in‐patient, in Germany, aged 55‐75 | |
| Interventions | Intervention: Piroxicam‐B‐cyclodextrin 10 mg oral once Control: Placebo |
|
| Outcomes | Cognition (ADAScog 0‐70 lower score = improvement) at 6 months | |
| Notes | Sources of funding not stated | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk |
No information Comment: probably not done |
| Allocation concealment (selection bias) | Unclear risk |
No information Comment: Probably not done |
| Blinding (performance bias and detection bias) All outcomes | Low risk |
Quote 1: all patients received either 10 mg piroxicam B Cyclodextrin or placebo Comment: Probably done, but there is only information for participants |
| Incomplete outcome data (attrition bias) All outcomes | Low risk |
Comment: Reasons for missing outcome data unlikely to be related to true outcome |
| Selective reporting (reporting bias) | High risk | Only report ADAS‐cog Comment: not all of the study’s pre‐specified primary outcomes have been reported. The study report fails to include results for a key outcome that would be expected to have been reported for such a study |
| Other bias | High risk |
Comment: had a potential source of bias related to the specific study design used Selection bias due to baseline imbalance |