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. 2004 Oct 26;383(Pt 3):401–412. doi: 10.1042/BJ20041051

Figure 2. NAS-91 and NAS-21 docked with homology-modelled FabZ from P. falciparum.

Figure 2

Pfal FabZ being a dimer, has two active sites, which, hence, can house either two molecules of NAS-21 or NAS-91, or one of each, simultaneously. In this Figure, however, for clarity, only one of the active sites has been demonstrated. While NAS-21 occludes the entry to the active site, NAS-91 sits in the active site and inhibits FabZ.