Figure 3. Superposition of the binary complex of FabI–NADH and the ternary complex of FabI–NAD⁺–triclosan.

Superposition of the binary complex of FabI–NADH (black) and the ternary complex of FabI–NAD⁺–triclosan (grey). Movement of residues 318–324 of the substrate-binding loop and the nicotinamide ring of NAD⁺ result in increased van der Waal's contacts, explaining the increased affinity of NAD⁺ and triclosan for FabI in the presence of triclosan and NAD⁺ respectively. TCL, triclosan.