FIGURE 1.

(A) Nociceptive sensory neuron endings grow into injured tissue following acute injury and release the neuropeptide calcitonin gene‐related peptide (CGRP). CGRP signalling in neutrophils and macrophages triggers the release of TSP‐1, which modulates these immune cells in an autocrine/paracrine manner to create a pro‐healing environment. (B) In the diabetic condition, there are fewer CGRP sensory neurons in tissues, and thus less CGRP is released at the site of injury, contributing to impaired tissue healing. (C) As a therapeutic approach, an engineered form of CGRP with improved pharmacokinetics is delivered into the injured tissue to accelerate the healing process.