Table 1. Cytochromes c and c1 from trypanosomatids contain a conserved single-cysteine haem-binding motif.
A high degree of overall sequence identity is also retained between the different trypanosomatids (>80% and >90% for cytochromes c and c1 respectively).
| Haem-binding motif | ||
|---|---|---|
| Organism | Cytochrome c | Cytochrome c1 |
| Trypanosoma brucei | AAQCH | FAPCH |
| Trypanosoma congolense | Not identified | FAPCH |
| Trypanosoma vivax | AAQCH | FAPCH |
| Trypanosoma cruzi | AAQCH | FAPCH |
| Crithidia oncopelti | AAQCH | FAPCH |
| Crithidia fasciculata | AAQCH | FAPCH |
| Leishmania major | AAQCH | FAPCH |
| Leishmania infantum | AAQCH | FAPCH |
| Euglena gracilis | AAQCH | FAPCH |
| Euglena viridis | AGQCH | Not identified |
| Saccharomyces cerevisiae | CLQCH (iso-1) | CAACH |
| CQQCH (iso-2) | ||
| Schizosaccharomyces pombe | CAQCH | CSACH |
| Homo sapiens | CSQCH | CASCH |
| Mus musculus | CAQCH | CSSCH |