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. 2024 Aug 21;43:240. doi: 10.1186/s13046-024-03149-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Non-typical circulating cells. A Representative image of a small non-typical circulating cell. B Representative image of a large non-typical circulating cell. Images were taken using a BioView Allegro Plus imaging system with a 10 × objective lens (CKs-AF488 in green, EpCAM-AF555 in orange, Blood lineage markers-APC in red/white in the merge image, nucleus-DAPI in blue). C Dot plot showing mean ± SEM of the number of non-typical circulating cells in each category in the harvest of 72 HV donors and 75 MBC (Two-Way ANOVA followed by Sidak’s multiple comparison test, ****P ≤ 0.0001). D Table shows the percentage donors with ≥ 1 non-typical blood cell. E Dot plot showing mean ± SEM of the number of non-typical circulating cells of each type in the harvest of 75 MBC (Two-Way ANOVA followed by Sidak’s multiple comparison test, *P ≤ 0.05) divided in patients receiving or not cytotoxic therapy. F Table shows median and range numbers of graph E