Table 2.
Results for IL-1β, IL-6, IL-8, IL-10, and TNF-α in MCF-7 co-culture model (percent positive sign indicates amount secreted)
| IL-1β | IL-6 | IL-8 | IL-10 | IL-α | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
|
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| Cell lines | Substances | % (−) | % (+) | % (−) | % (+) | % (−) | % (+) | % (−) | % (+) | % (−) | % (+) |
| THP-1 | Control | 96.2 | 3.8 | 91.1 | 7.7 | 85.5 | 14.2 | 90.0 | 9.7 | 86.9 | 12.7 |
| 100 ng/mL LPS | 57.6 | 42.4 | 76.4 | 20.1 | 53.7 | 44.4 | 77.3 | 22.1 | 68.6 | 30.9 | |
| MCF-7 | Control | 93.8 | 6.2 | 81.2 | 18.5 | 77.3 | 20.2 | 88.6 | 11.0 | 79.8 | 19.9 |
| Co-culture | Control | 89.6 | 10.4 | 89.4 | 10.3 | 42.7 | 56.1 | 65.8 | 33.3 | 54.8 | 44.2 |
| Tamoxifen IC50 | 94.1 | 5.9 | 80.6 | 19.2 | 80.1 | 18.7 | 87.0 | 12.6 | 78.4 | 21.1 | |
| Escitalopram oxalate IC50 | 97.2 | 2.8 | 88.7 | 11.1 | 83.8 | 15.6 | 88.9 | 10.6 | 87.7 | 12.1 | |
IL, interleukin.