Table 3.

Definitions of PrEP outcomes

PrEP route	Persistence definition
Oral daily	Consistent PrEP prescription refills, from a participant’s PrEP initiation (or re-initiation) until a missed refill by >14 days for any reason
Event-driven	Consistent attendance at each quarterly clinic visits with refills as provided by the clinician until a missed visit by >14 days for any reason
LAI	Consistent receipt of injection every 8 weeks until missed injection by >14 days for any reason
PrEP route	Adherence definition
Oral daily	Two thresholds: ≥ 4 days/week, a threshold consistent with HIV prevention among MSM, and 7 days/week, indicating perfect adherence [57].
Event-driven	Completion of the 2+1+1 regimen for every reported anal or vaginal intercourse event.
All routes of PrEP uptake	Risk-aligned PrEP use definition
	PrEP use is consistent with concurrent risk behavior, including: • persistent oral, event-driven or injectable PrEP ➢ clinician-approved PrEP discontinuation for reduced sexual risk