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. Author manuscript; available in PMC: 2024 Aug 21.
Published in final edited form as: Sci Transl Med. 2024 Jul 3;16(754):eadk3295. doi: 10.1126/scitranslmed.adk3295

Figure 7. SARS-CoV-2 Spike protein-encoding double-stranded (ds)RNA was observed in recto-sigmoid tissue from individuals with LC months to years following acute infection.

Figure 7.

Red arrows and the red circle denote representative areas of dsRNA detection in cells across images for each sample. Spike protein-encoding dsRNA was detected in three of the post-acute COVID-19 participants who underwent biopsy from 213 to 676 days following initial COVID-19 symptom onset, and the signal was primarily observed exclusively in cells located within the lamina propria. Four representative participants are shown. No viral dsRNA was detected in the control tissue from a pre-pandemic participant.