Table 3. Summary of phenotypes of NF-κB1 and TPL-2 knockout mice.
Abbreviations and symbols used: ↑, increase; ↓, decrease; =, unaffected; Ab, antibody; Ag, antigen; sCD40L, soluble CD40 ligand; mCD40L, membrane-bound CD40 ligand; D-Gal, D-galactosamine; LCMV, lymphocytic choriomeningitis virus; LN, lymph node.
| Macrophages | T-cells | B-cells | Other comments | Reference(s) | |
|---|---|---|---|---|---|
| nf-κb1−/− (no p105/p50, TPL-2/ABIN-2 ↓) | LPS: | αCD3+αCD28: | LPS, sCD40L: | Morphology/development= | [141–143,158,161,165] |
| MEK/ERK activation ↓ | Proliferation ↓ | Proliferation ↓ | |||
| COX-2, IL-6, IL-12, MCP1 ↓ | IL-2R ↓ | αIgM, mCD40L: | |||
| Proliferation= | |||||
| TH2 differentiation ↓ | Ab isotype switch ↓ | ||||
| GATA-3 ↓ | Ag-specific Abs ↓ (T-dependent) | ||||
| nf-κb1ΔC/ΔC (no p105, high p50) (TPL-2, ABIN-2 ↓?) | LPS: | αCD3+αCD28: | LPS, αIgM: | Enlarged LN, splenomegaly, lymphoid hyperplasia | [101] |
| IL-1β, IL-6, IL-10, TNFα ↓ | Proliferation ↓ | Proliferation ↑ | |||
| IL-2, IL-4, TNFα ↓ | |||||
| Basal Ig ↑ | |||||
| Ag-specific Abs ↑ (T-dependent) | Die post-natally | ||||
| tpl-2−/− | LPS: | αCD3+αCD28: | αCD40: | Morphology/development= | [138–140,188] |
| MEK/ERK activation ↓ | Proliferation= | MEK/ERK activation ↓ | |||
| TNFα, IL-1, COX-2 ↓ | IL-2, TNFα, IFN-γ= | Proliferation= | |||
| TNFα, αCD40: | CD54, CD69, CD44, CD95= | Septic shock ↓ (LPS/D-Gal) | |||
| MEK/ERK activation ↓ | Cytotoxic response (LCMV)= | Ag-specific Ab= | Inflammatory bowel disease ↓ |