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. 2024 Jul 26;106:105260. doi: 10.1016/j.ebiom.2024.105260

Fig. 1.

Fig. 1

Variations in Erbb2-initiated tumour phenotypes across F1 hybrids of 30 Collaborative Cross (CC) strains and FVB/N MMTV-Erbb2 (CC F1) mice. (a) Tumour onset of 732 CC F1 of 30 CC strains and 20 FVB/N MMTV-Erbb2 mice. Left panel: The Kaplan–Meier curve for tumour-free survival in each CC F1 strain and FVB/N MMTV-Erbb2 mice. The curve for FVB/N (control) mice was highlighted with a bold red line. Right Panel: median time of tumour onset in each CC F1 strain and FVB/N MMTV-Erbb2 mice. The bars show the 95% confidence interval for median time. (b) Multiplicities in the same cohort of mice. Box plot for number of tumours in each CC F1 strain. The low edge of the box represents the lower quartile, while the upper edge of the box represents the upper quartile. The open circles on the diagram show the outliers. (c) Frequencies of metastasis in different sites across 30 CC F1 strains. (d) The correlation between tumour onset and multiplicities was assessed by the Spearman's rank correlation coefficient and p value. (e) The correlation between tumour onset and metastasis was assessed by the Mann–Whitney U test.