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. Author manuscript; available in PMC: 2024 Aug 21.
Published in final edited form as: J Clin Psychiatry. 2024 Jul 15;85(3):24m15258. doi: 10.4088/JCP.24m15258

Table 3.

Prevalence of POUD by Health Conditions, Functional Disabilities, and Behavioral Health Status Within and Across Prescription Opioid Misuse Status Among US Adults With Past-Year Use of Prescription Opioids

Health conditions, functional disabilities, and behavioral health status Adults reporting Rx opioid misuse n = 1,556 wtd % (95% CI) Adults reporting Rx opioid use without misuse n = 9,534 wtd % (95% CI) Prevalence ratioa (95% CI)
Health conditions

Self-rated health
  Excellentb 9.1 (5.0–15.9) 2.3 (1.1–4.6) 4.0 (1.6–10.0)
  Very good 12.0 (8.0–17.5) 2.7 (1.8–4.0) 4.5 (2.5–8.1)
  Good 26.2 (20.5–32.8) 3.6 (2.8–4.6) 7.3 (5.2–10.4)
  Fair/poor 33.5 (23.8–44.8) 10.6 (8.7–12.8) 3.2 (2.3–4.4)

PY emergency department visit
  0b 18.1 (14.4–22.6) 3.6 (2.9–4.6) 5.0 (3.6–6.8)
  1–2 27.8 (20.9–36.0) 4.3 (3.2–5.8) 6.5 (4.2–9.9)
  ≥3 32.0 (20.4–46.4) 16.4 (11.5–23.0) 1.9 (1.1–3.5)

Hypertension
  Yes 26.8 (18.8–36.6) 6.8 (5.3–8.8) 3.9 (2.6–5.9)
  Nob 20.6 (17.1–24.6) 4.0 (3.4–4.9) 5.1 (3.9–6.7)

Heart disease
  Yes 38.5 (25.4–53.5) 8.3 (5.6–12.1) 4.6 (2.7–7.9)
  Nob 19.7 (16.4–23.4) 4.1 (3.4–5.0) 4.8 (3.7–6.2)

Diabetes mellitus
  Yes 26.2 (15.7–40.5) 8.2(5.9–11.3) 3.2 (1.8–5.7)
  Nob 21.2 (17.7–25.2) 4.1 (3.3–5.1) 5.1 (3.9–6.7)

Cancer
  Yes c 7.1 (4.4–11.3) c
  Nob 22.5 (19.1–26.2) 4.5 (3.9–5.3) 4.9 (3.9–6.3)

Asthma
  Yes 24.9 (16.2–36.3) 7.0 (4.7–10.2) 3.6 (2.1–6.1)
  Nob 21.2 (17.7–25.2) 4.5 (3.7–5.3) 4.7 (3.7–6.2)

COPD
  Yes c 10.7 (7.0–15.9) c
  Nob 21.0 (17.8–24.5) 4.2 (3.6–5.0) 5.0 (3.9–6.3)

Hepatitis B or C
  Yes c 12.8 (6.5–23.7) c
  Nob 21.4 (18.0–25.1) 4.6 (3.9–5.4) 4.6 (3.6–6.0)
Functional disabilities
Hearing disability
  Yes 22.0 (16.6–28.4) 7.0 (5.3–9.3) 3.1 (2.0–4.8)
  Nob 22.2 (18.2–26.8) 4.2 (3.5–5.0) 5.3 (4.0–7.0)

Vision disability
  Yes 25.9 (19.8–33.2) 8.0 (6.4–9.9) 3.3 (2.3–4.7)
  Nob 19.3 (15.8–23.3) 3.2 (2.6–4.1) 6.0(4.3–8.2)

Cognition disability
  Yes 27.5 (22.2–33.5) 8.0 (6.5–9.8) 3.4 (2.6–4.6)
  Nob 16.6 (12.6–21.4) 2.8 (2.2–3.5) 6.0 (4.1–8.7)

Mobility disability
  Yes 34.5 (24.9–45.5) 8.9 (7.4–10.7 3.9 (2.9–5.2)
  Nob 17.1 (13.6–21.2) 2.8 (2.0–3.8) 6.2 (4.1–9.1)

Communication disability
  Yes 37.5 (28.4–47.5) 11.3 (8.5–14.7) 3.3 (2.3–4.9)
  Nob 19.5 (15.7–23.9) 4.2 (3.5–5.0) 4.7 (3.5–6.3)

Self-care disability
  Yes 37.7 (27.0–49.7) 13.6 (10.4–17.7) 2.8 (1.9–3.9)
  Nob 19.1 (15.3–23.5) 3.9 (3.1–4.8) 4.9 (3.6–6.8)

Sum of disabilities
  0b 14.5 (10.5–19.6) 1.5 (1.0–2.4) 9.4 (5.4–16.3)
  1 15.4 (10.4–22.2) 4.2 (2.9–6.0) 3.7 (2.3–6.0)
  2 28.1 (20.4–37.4) 4.2 (2.6–6.7) 6.7 (3.5–13.0)
  3 23.3 (14.9–34.6) 7.3 (4.9–10.8) 3.2 (1.8–5.8)
  ≥4 39.3 (28.6–51.1) 14.2 (10.8–18.4) 2.8 (1.9–4.0)
Mental health problems
PY MDE
  Yes 33.9 (24.7–44.5) 12.0 (9.3–15.3) 2.8 (2.0–4.1)
  Nob 18.3 (14.5–22.9) 4.0 (3.3–4.9) 4.6 (3.3–6.3)

PY suicidal ideation
  Yes 34.4 (23.8–46.8) 10.9 (7.0–16.6) 3.2 (1.8–5.5)
  Nob 20.3 (16.7–24.5) 4.6 (3.8–5.5) 4.4 (3.4–5.7)
Substance use problems
PM nicotine dependence
  Yes 38.7 (30.7–47.3) 9.4 (7.3–12.0) 4.1 (2.9–5.7)
  Nob 15.5 (12.7–18.7) 4.1 (3.3–5.0) 3.8 (2.9–5.0)

PY alcohol use and disorder
  Use disorder 26.4 (20.6–33.0) 6.0 (4.3–8.5) 4.4 (2.9–6.5)
  Use, no disorder 15.6 (11.7–20.5) 2.8 (2.1–3.6) 5.6 (4.0–8.0)
   useb 29.7 (21.4–39.7) 8.4 (6.6–10.6) 3.5 (2.4–5.2)

PY cannabis use and disorder
  Use disorder 27.8 (20.2–37.0) 8.6 (4.8–15.1) 3.2 (1.7–6.0)
  Use, no disorder 17.6 (12.1–25.0) 4.2 (2.9–6.2) 4.2 (2.5–7.1)
  No useb 22.0 (16.7–28.3) 4.8 (4.0–5.8) 4.6 (3.4–6.3)

PY cocaine use and disorder
  Use or use disorder 45.5 (33.1–58.4) 9.0 (3.6–20.9) 5.0 (2.0–12.8)
  No useb 18.2 (15.1–21.8) 4.8 (4.1–5.7) 3.8 (2.9–4.9)

PY heroin use and disorder
  Use or use disorder 69.5 (53.6–81.8) 17.1 (5.2–43.8) 4.1 (1.3–12.5)
  No useb 18.5 (15.5–21.9) 4.9 (4.2–5.7) 3.8 (3.0–4.8)

PY Rx sedative/tranquilizer use, misuse, or use disorder
  Use disorder 82.8 (71.2–90.4) 36.2 (23.6–51.1) 2.3 (1.5–3.4)
  Misuse, no disorder 18.3 (11.3–28.3) 14.6 (5.9–31.7) 1.3 (0.4–3.6)
  Use, no misuse, no disorder 19.8 (13.4–28.2) 6.1 (4.7–8.0) 3.2 (2.0–5.2)
  No useb 14.9 (11.0–19.8) 3.7 (3.0–4.5) 4.1 (2.9–5.7)

PY Rx stimulant use, misuse, or use disorder
  Use disorder 76.5 (65.5–84.8) 21.8 (11.0–38.7) 3.5 (1.8–6.7)
  Misuse, no disorder 22.2 (13.8–33.8) 00.6 (0.1–4.8) 35.0 (4.2–290.8)
  Use, no misuse, no disorder 15.3 (8.5–26.1) 4.5 (2.7–7.6) 3.4 (1.8–6.5)
  No useb 20.4 (16.4–25.1) 4.9 (4.1–5.8) 4.2 (3.2–5.5)
a

For each prevalence ratio, the reference group is the group of adults reporting Rx opioid use without misuse.

b

Within each group, bolded estimates were statistically significantly different from the corresponding estimate from the reference group indicated with superscript b (P < .05).

c

Estimate suppressed due to low statistical precision.

Abbreviations: COPD = chronic obstructive pulmonary disease, MDE = major depressive episode, PM = past-month, POUD = prescription-related opioid use disorder, PY = past-year, Rx = prescription, wtd = weighted.