Table 1 –
Univariable Comparison Of Pre-transfer Characteristics According To The Inter-Hospital Recanalization Status
| Overall N=520 |
Recanalization N=111 |
No Recanalization N=409 |
P-value | |
|---|---|---|---|---|
| Age | 72 (61–81) | 74 (62–82) | 71 (61–81) | 0.23 |
| Male | 284 (55) | 66 (60) | 218 (53) | 0.25 |
| Hypertension | 349 (67) | 66 (60) | 283 (69) | 0.05 |
| Diabetes | 112 (22) | 16 (14) | 96 (24) | 0.04 |
| Dyslipidemia | 200 (39) | 41 (37) | 159 (39) | 0.71 |
| Pre-stroke antiplatelets | 166 (32) | 39 (35) | 127 (32) | 0.48 |
| Pre-stroke anticoagulant | 81 (16) | 12 (11) | 69 (17) | 0.10 |
| Center | 0.34 | |||
| Stanford | 283 (54) | 56 (50) | 227 (56) | |
| Montpellier | 237 (46) | 55 (50) | 182 (44) | |
| Clinical characteristics | ||||
| NIHSS score | 15 (10–20) | 15 (10–20) | 15 (10–20) | 0.75 |
| Glucose, mg/dL | 119 (104–143) | 114 (101–129) | 120 (106–149) | <0.01 |
| Systolic blood pressure, mmHg | 148 (128–167) | 148 (127–162) | 148 (130–168) | 0.20 |
| Imaging characteristics | ||||
| LSW-to-imaging, hrs | 2.3 (1.3–6.4) | 1.8 (1.1–2.9) | 2.8 (1.4–7.7) | <0.01 |
| Occlusion site | <0.01 | |||
| ICA | 109 (21) | 9 (8) | 100 (24) | |
| M1 proximal | 175 (34) | 29 (26) | 146 (36) | |
| M1 distal | 140 (27) | 46 (41) | 94 (23) | |
| M2 | 96 (19) | 27 (24) | 69 (17) | |
| Associated cervical ICA occlusion | 99 (19) | 17 (15) | 82 (20) | 0.26 |
| Clot burden score (n=489)a | <0.01 | |||
| 0–4 | 103 (21) | 8 (8) | 95 (25) | |
| 5–7 | 224 (46) | 49 (46) | 175 (46) | |
| 8–9 | 162 (33) | 49 (46) | 113 (30) | |
| Infarct volume, mL (n=474)b | 10 (0–25) | 10 (0–21) | 10 (0–25) | 0.82 |
| HIR (n=275)c | 0.43 (0.23–0.54) | 0.42 (0.22–0.54) | 0.43 (0.23–0.54) | 0.98 |
| IV-thrombolysis use | 259 (50) | 91 (82) | 168 (41) | <0.01 |
| Transfer time, hours | 3.0 (2.5–3.7) | 3.1 (2.5–3.7) | 3.0 (2.5–3.7) | 0.32 |
Categorical variables are expressed as numbers (%) and continuous variables as median (interquartile range).
Clot burden score was evaluated on CT-angiography or T2*/SWI imaging (susceptibility vessel sign). Data was missing in 31/520 (6%) patients without susceptibility vessel sign on T2*/SWI imaging (5 [5%] in the recanalization group and 26 [6%] in the non recanalization group).
Infarct volume was measured on diffusion-weighted imaging (manual delineation) or CT-perfusion (relative cerebral blood flow <30%). Data was missing in 46/520 (9%) patients without CT-perfusion or diffusion-weighted imaging (8 [7%] in the recanalization group and 38 [9%] in the non recanalization group).
HIR was defined as the proportion of Tmax>6s volume with Tmax>10s (i.e. Tmax>10s volume / Tmax>6s volume), low HIR indicating milder hypoperfusion and better collaterals. Data was missing in 245/520 (47%) patients without perfusion imaging (52 [47%] in the recanalization group and 193 [47%] in the non recanalization group).