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. 2004 Jul 27;381(Pt 3):561–579. doi: 10.1042/BJ20040752

Figure 7. Conserved C-terminal domains in the heart and brain/placenta PFK-2/FBPase-2 isoenzymes.

Figure 7

The C-terminal sequence of human heart PFK-2/FBPase-2 containing the phosphorylation sites, Ser466 and Ser483, was aligned by eye with C-terminal sequences of the heart isoenzyme from other species and with the brain/placenta isoenzyme. The residue corresponding to Ser466 is in a suitable consensus for phosphorylation by AMPK in all sequences, whereas the brain/placenta isoenzyme lacks the −5 arginine residue for phosphorylation by insulin-stimulated protein kinases, although phosphorylation by PKA and PKC would still be expected (see text).