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. 2004 Jul 27;381(Pt 3):561–579. doi: 10.1042/BJ20040752

Table 1. Mammalian FPK-2/FBPase-2 gene products.

All the mRNAs listed, except M and F, differ in terms of coding sequence. The M isoform is sometimes called the muscle isoenzyme. Only the mRNAs from gene 1 (formerly called gene A) are referred to in the literature as indicated. We propose here an ad hoc nomenclature for the other mRNAs. As gene 2 was called gene B, its transcripts were referred to earlier as B1 to B4. Some of the isoforms are coded by more mRNAs than indicated, due to transcription from several promoters and due to differential splicing with non-coding exons. See text for explanations and references.

Gene Chromosome locus Isoenzyme mRNA Isoform
PFKFB1 Human Xp11.21 Liver L L
Rat Xq22-q31 M M
F M
PFKFB2 Human 1q31 Heart H1, H2, H4 Long (58 kDa)
Rat 13 H3 Short (54 kDa)
PFKFB3 Human 10p14-p15 Brain/placenta U Ubiquitous
Rat 17q12.3 I Inducible
PFKFB4 Human 3p21-p22 Testis T T
Rat 8q32