Fig. 5. RNU4-2 is more highly expressed than RNU4-1 in the prefrontal cortex.

a, Levels of RNU4-1 (grey) and RNU4-2 (teal) expression in human dorsolateral prefrontal cortex at different developmental stages from BrainVar²³. Coloured lines correspond to the Loess smoothed average with the shaded regions representing 95% CIs. Developmental stages are labelled with periods (1 to 12), spanning from embryonic development to late adulthood, that were defined previously⁴². b, ATAC-seq data from human prenatal prefrontal cortex shows substantially higher peaks of chromatin accessibility around RNU4-2 than RNU4-1. Data for both 18 and 19 gestational weeks (GW) are shown to demonstrate replication.