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. 2024 Jul 11;632(8026):832–840. doi: 10.1038/s41586-024-07773-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — Comparison of (a) paternal age for probands with fathers and (b) maternal age for probands with mothers recruited into GEL for individuals with variants in RNU4-2 (teal) and all other NDD probands (grey). Centre line, median; box limits, upper and lower quartiles; whiskers, 1.5x interquartile range. Individual data points, including outliers, are not shown due to Genomics England restrictions. NS: not significant. Paternal age: mean 33.1 vs 33.4 in individuals with RNU4-2 variants and other NDD probands, respectively (two-sided t-test P-value = 0.771; t = −0.29 (−2.41 - 1.80)). Maternal age: mean 30.2 vs 29.7 in individuals with RNU4-2 variants and other NDD probands, respectively (two-sided t-test P-value = 0.505; t = −0.67 (−1.07 - 2.15)).