Table 2. Parameters of the model describing intrinsic tenase on activated platelets (Model 2).

Experimentally determined parameter	Experimental value	Experimental conditionsa	Reference	Relationship between model and experimental parameters	Value used in the model
Vmax	12.4 nM·min−1	[IXa]=10 pM, [VIIIa]=5 units·ml−1 n=5×107 platelets·ml−1	[13]	Eqn A71	kcatlocal=6350 min−1
	2.5 nM·min−1	[IXa]=1 nM, [VIIIa]=5 units ml−1n=5×107 platelets·ml−1	[41]	Eqn A77
Km (app)	160 nM	[IXa]=10 pM, [VIIIa]=5 units·ml−1n=5×107 platelets·ml−1	[13]	Eqn A71	Kmlocal/k=1216 molecules/platelet
	22.6b nM	[IXa]=1 nM, [VIIIa]=5 units ml−1n=5×107 platelets·ml−1	[41]	Eqn A76
KdIX (app)	0.56 nM	fVIIIa and fX were in saturation	[19]	Eqn A68	KdIXa-VIIIa local/k=278 molecules/platelet
KdX	320 nM	–	[20]	–	320 nM
nX	16000 sites/platelet	–	[20]	–	16000 sites/platelet
KdIXa	2.57 nM	–	[19]	–	2.57 nM
nIXa	250 sites/platelet	–	[19]	–	250 sites/platelet
KdVIIIa	1.5 nM	–	[21]	–	1.5 nM
	1.7 nM		[49]
nVIIIa	750 sites/platelet	–	[21]	–	750 sites/platelet
KdVIIIa-X (app)	30 nM	–	[21]	Eqn A66	KdVIIIa-X local/k=1655 molecules/platelet

^a Only the data necessary to obtain the model parameters from the corresponding experimentally determined parameters are presented in this column.

^b The values used in the model are underlined.