Table 3. Binding of coagulation factors to thrombin-activated platelets: theoretical resultsa.
Ligand | Two other factors | Number of binding sites/platelet (n) | Kd (app) (nM) |
---|---|---|---|
fIXa | Absentb | 250 | 2.57 |
Presentc | 250 | 0.69 | |
fVIIIa | Absentb | 750 | 1.5 |
Presentc | 926 (750 and 193)d | 1.1 (1.5 and 0.34)d | |
fX | Absentb | 16000 | 320 |
Presentc | 16002 and 755d | 320 and 28.7d |
a The conditions of calculations are given in the legend to Figure 5.
b Fixed values.
c Obtained values.
d Fitting to the two-site binding model.