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. 2004 Jul 27;381(Pt 3):831–840. doi: 10.1042/BJ20031930

Figure 3. Amino acid sequences of lobster HMGR1 and HMGR2 are closely related to other class I HMGR proteins.

Figure 3

The sequences of lobster HMGR1 and HMGR2 (lob-HMGR1 and HMGR2) were compared with the HMGRs of the cockroach B. germanica [15] and the beetle Ips paraconfusus [21], the fruitfly D. melanogaster [24] and the human Homo sapiens [36]. Only residues 1–80 of lob-HMGR1 are shown; the rest of its sequence is identical with residues 138–655 of lob-HMGR2. Conserved residues are shown as white letters with a black background, similar residues as white letters with a light grey background, non-conserved residues as black letters with a white background and gaps inserted to optimize the alignment are shown by a broken line. The putative transmembrane region of HMGR2 (residues 4–27) is shown with a bar and the putative PEST region (residues 549–585 of HMGR2) is shown with a broken line. The conserved catalytic histidine (residue 540 in HMGR2) is marked by an *. A valine (residue 546 in HMGR2) that replaces the serine that is phosphorylated in class I HMGRs from other higher eukaryotes is marked by #.