Fig. 3.

a, b Total ROS (a) and superoxide (b) production in the brain cortical tissue of 5xFAD mice and wild-type (WT) mice. The data are presented as mean ± SEM of 5 animals per condition. *p < 0.05 compared to WT mice, Student’s t-test. c, d Gene expression of sirtuin-3 (Sirt3; c) and interleukin-1 beta (Il1b; d) in the brain cortical tissue of 5xFAD and wild-type (WT) mice. The data are present as mean ± SEM of 7 animals per condition. The gene expression was normalized against the beta-actin (Actb) house-keeping gene. ***p < 0.001; ****p < 0.0001 compared to WT mice, Student’s t-test