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. 2024 Aug 21;15:7154. doi: 10.1038/s41467-024-51328-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 3 — a Uniform Manifold Approximation and Projection (UMAP) plot of cell clusters detected by unsupervised graph clustering of cell populations from Esco2^fl/fl (left) and Esco2^fl/fl;Prrx1-Cre^Tg/0 (right) limb buds. b UMAP of the 25 marker genes expressed in DM8 that intersect with the DEGs identified in the bulk RNA-seq data at E9.5. c Gene ontology (GO) enrichment for upregulated and downregulated markers in DM8. Gene Ontology enrichment analysis was performed with a p-value ranked query and multiple testing correction by the g:SCS method (p ≤ 0.05). Dashed line indicates the threshold of significance (0.05).