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. 2024 Aug 21;14:19383. doi: 10.1038/s41598-024-70335-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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90% Pancreatectomy induced a diabetic phenotype, and protected against isoprenaline induced mortality. Sprague Dawley rats underwent 90% pancreatectomy (Px) or sham operation at week 0. Starting at 5 weeks, rats were administered once daily 1 mg/kg isoprenaline (Iso) or saline (vehicle) for 10 days. (A) Bodyweight (B) Fasted blood glucose and (C) Survival are charted over time following operation until termination of the study at 10 weeks. All displayed as mean ± SD, n = 12–18 for all groups in (A,B); n = 21–22 per group for (C).