Table 1.

Summary of the probe selection criteria for the robust, intermediate, and combined cohorts

	Robust episignature	Intermediate episignature	Combined episignature
Number of cases	23	23	40
Number of controls	46	69	80
$i$	900	800	800
$j$	450	400	400
$k$	0.7	0.6	0.95
Number of selected probes	271	255	377
Model’s specificity	99.16%	98.76%	98.32%

$i$: the number of probes with the highest products of mean methylation difference and negative of the logarithm of p values selected in the first step of probe selection; $j$: the number of probes with the highest AUC selected in the second step of probe selection; $k$: the cut-off for removing the highly correlated probes in the third step of probe selection.