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. 2004 Sep 7;382(Pt 3):913–921. doi: 10.1042/BJ20040432

Figure 8. A model for the relation between FXR-mediated transcription to regulate the bile acid biosynthesis and PGC-1α-mediated transcription.

Figure 8

A model is presented for the possible relation among the induction of PGC-1α by the environmental stimuli such as starvation [32], co-activation of FXR-mediated SHP transcription by PGC-1α, transcriptional repression of CYP7A1 by the suppression of LRH-1 by SHP [9,10] and suppression of bile acid biosynthesis, co-activation of HNF-4α-mediated CYP7A1 transcription [43] by PGC-1α and activation of bile acid biosynthesis, and activation of PEPCK by the coupling of HNF-4α and PGC-1α [32].