| Study name |
A randomised controlled clinical trial to compare the efficacy of standard dose of steroids vs reduced dose in treating relapses in children with steroid sensitive nephrotic syndrome |
| Methods |
Study design
Parallel, open‐label RCT Follow‐up: 6 months
|
| Participants |
Study characteristics
60 children aged 1 to 18 years All children with idiopathic nephrotic syndrome on stable immunosuppression (either long‐term alternate‐day steroids, levamisole or MMF) or on no immunosuppression for the last 6 months with infrequent relapses defined as < 2 relapses in the last 6 months
|
| Interventions |
Intervention group
Control group
Prednisolone: 1.5 mg/kg every alternate day to treat relapse Duration unclear but same as intervention group No information on prednisone dose/duration to achieve remission
|
| Outcomes |
Planned outcomes
Proportion of frequent relapsers on the reduced dose regime as compared to standard regime Number of relapses in children in whom steroid dose is reduced to 1mg/kg on alternate days for 4 weeks instead of the standard 1.5 mg/kg every alternate day in 6 months Cumulative steroid dose in two groups for 6 months
|
| Starting date |
1/6/2018 |
| Contact information |
Associate Professor Suprita Kalra
Email: kalrasuprita@gmail.com |
| Notes |
Children with SRNS or SSNS commenced on steroid sparing agent in past 6 months because of FRNS or SDNS |
