Table 3. Genetic Perturbagens with the Top Positive CMap Connectivity Scores to Clorgyline.
| No. | gene | scorea | type | description | validationb |
|---|---|---|---|---|---|
| 1 | GAMT | 99.82 | kd | methyltransferase | apoptosis61 |
| 2 | PDX1 | 99.49 | kd | homeoboxes/ANTP class; HOXL subclass | regulates pancreatic ductal adenocarcinoma initiation and maintenance62 |
| 3 | ATG12 | 99.45 | kd | autophagy-related 12 | cancer prognosis63 |
| 4 | G6PD | 99.42 | kd | glucose-6-phosphate dehydrogenase | cancer growth64 |
| 5 | FYN | 99.37 | kd | Src family | cancer growth, metastasis, apoptosis, migration, chemotherapy resistance65 |
| 6 | ANXA1 | 99.26 | kd | annexins | tumorigenesis biomarker66 |
| 7 | NRBP2 | 99.08 | kd | NRBP family | tumor suppressor67 |
| 8 | TSPAN8 | 98.89 | kd | tetraspanins | cancer cell stemness, chemotherapy resistance68 |
| 9 | CDX1 | 98.89 | kd | homeoboxes/ANTP class: HOXL subclass | tumor suppressors69 |
| 10 | FST | 98.79 | kd | follistatin (FST) is a secretory glycoprotein | tumorigenesis, metastasis, angiogenesis of solid tumors70 |
a
Score refer to the CMap score. It represents the level of similarity between transcriptional effects induced by clorgyline and each of the compound perturbagens shown in the table.
b
Validation refers to the presence of any supporting evidence from the biomedical literature that the predicted positive gene connections to clorgyline have anticancer effects.