Table 4. Top 10 Causal Reasoning Hubs for Clorgyline’s GS.

No.	molecular entity	gene	predicted activity	activity prediction p-value	distance	validation
1	OTUD1	OTUD1	–	6.64 × 10–12	3	Exacerbates colon cancer progression.71
2	GHET1	GHET1	+	8.48 × 10–12	3	Knockdown of long noncoding RNA GHET1 inhibits cell proliferation and invasion of colorectal cancer.72
3	miR-24-3p	MIR24-1	–	8.89 × 10–12	2	miR-24-3p promotes colon cancer progression by targeting ING1.73
		MIR24-2
4	RNF12	RLIM	–	8.89 × 10–12	3	Ring finger protein 2 promotes colorectal cancer progression by suppressing early growth response 1.74
5	PSMA3	PSMA3	+	2.09 × 10–11	3	PSMA3-AS1, is an antisense RNA molecule that is transcribed from the opposite DNA strand of the PSMA3 gene, and it regulates PSMA3. PSMA3-AS1 promotes colorectal cancer cell migration and invasion via regulating miR-4429.75
6	MALAT1	MALAT1	+	2.58 × 10–11	2	MALAT1 expression is associated with CRC cell proliferation, tumorigenicity, and metastasis.76
7	tubulin alpha-1B	TUBA1B	–	2.74 × 10–11	3	Has oncogenic role in some human cancers.
8	endophilin A2	SH3GL1	+	2.87 × 10–11	3	Has oncogenic role in some human cancers.
9	miR-24-3p	MIR24-1	–	3.00 × 10–11	3	miR-24-3p promotes colon cancer progression by targeting ING1.73
		MIR24-2
10	miR-572	MIR572	+	4.48 × 10–11	3	Contributes to CRC progression.77