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. 2024 Aug 9;9(33):35703–35717. doi: 10.1021/acsomega.4c04100

Table 5. Top 10 Pathway Maps Enriched with Clorgyline’s DEGs.

No. pathway map union p-value DEG p-value key hubs p-value direction
1 ligand-independent activation of androgen receptor in prostate cancer 4.91 × 10–10 5.68 × 10–04 4.34 × 10–07 NA
2 role of microRNAs in cell proliferation in colorectal cancer 1.37 × 10–08 3.66 × 10–02 2.06 × 10–07 NA
3 development_androgen receptor in reproductive system development 4.67 × 10–08 7.75 × 10–03 3.02 × 10–06
4 WNT signaling in the progression of lung cancer 5.89 × 10–08 8.11 × 10–03 3.59 × 10–06 NA
5 DNA damage_double-strand break repair via homologous recombination 6.40 × 10–08 2.37 × 10–04 1.30 × 10–05 +
6 TGF-beta signaling via kinase cascades in breast cancer 1.50 × 10–07 2.26 × 10–02 5.85 × 10–07 NA
7 regulation of GSK3 beta in bipolar disorder 1.74 × 10–07 1.14 × 10–02 8.40 × 10–06 NA
8 signal transduction_S1P1 receptor signaling 3.27 × 10–07 2.71 × 10–02 5.72 × 10–06 NA
9 DNA damage_ATM activation by DNA damage 3.69 × 10–07 7.48 × 10–04 1.24 × 10–04 NA
10 role of inhibition of WNT signaling in the progression of lung cancer 8.35 × 10–07 4.13 × 10–02 1.24 × 10–05 NA