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. 2024 Aug 9;9(33):35703–35717. doi: 10.1021/acsomega.4c04100

Table 7. Micromolar (μM) GI50 Values for Doxorubicin Alone and in Combination with a MAO-A Inhibitor Clorgyline Treatment in Colorectal Cancer Cell Linesa.

  HCT116
Caco2
SW480
SW620
HT29
time (h) Doxo Comb Doxo Comb Doxo Comb Doxo Comb Doxo Comb
24 4.92 1.29 352.26 3.19 NA NA 17.37 2.04 2.80 1.50
48 0.15 0.15 42.77 2.29 NA NA 0.28 0.27 0.43 0.41
72 0.14 0.12 1.79 0.65 NA NA 0.11 0.07 0.28 0.27
a

SD is not reported here since none exceeded 5%. h: hour; Doxo: doxorubicin; Comb: combination of doxorubicin and clorgyline [1:100] GI50 (μM).