Table 2.
Univariate and multivariate analysis of risk factors for 28-day mortality in patients with KP-BSIs
| Variables | No survivors(n = 39) | Survivors (n = 95) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | |||
| Demographic | ||||||
| Gender Male, n(%) | 28 (71.8) | 58 (61.1) | 1.624 (0.722–3.651) | 0.241 | ||
| Age (Years, mean ± SD) | 68.6 ± 15.5 | 67.2 ± 17 | 1.004 (0.982–1.027) | 0.695 | ||
| Hospital stay before BSIs, days (median, IQR) | 17 (7, 33) | 2 (1, 13) | 1.040 (1.017–1.064) | 0.001 | ||
| Microbiologic eradication after 6 days | 18 (46.2) | 10 (10.5) | 7.286 (2.937–18.076) | < 0.0001 | 3.569 (1.119–11.387) | 0.032 |
| Underlying diseases | ||||||
| Hepatobiliary and pancreatic diseases | 9 (23.1) | 43 (45.3) | 0.363 (0.155–0.847) | 0.019 | ||
| Kidney diseases | 12 (30.8) | 25 (26.3) | 1.244 (0.549–2.823) | 0.601 | ||
| Chronic lung diseases | 10 (25.6) | 12 (12.6) | 2.385 (0.932–6.104) | 0.070 | ||
| Diabetes mellitus | 12 (30.8) | 40 (42.1) | 0.611 (0.277–1.350) | 0.223 | ||
| Cardiovascular diseases | 21 (53.8) | 39 (41.1) | 1.675 (0.791–3.549) | 0.178 | ||
| Hypoproteinemia | 27 (69.2) | 63 (66.3) | 1.143 (0.512–2.549) | 0.744 | ||
| CCI score (median, IQR) | 5 (3.5, 6) | 4.5 (3, 6) | 0.986 (0.834–1.165) | 0.866 | ||
| Invasive procedures | ||||||
| Mechanical ventilation | 18 (46.2) | 19 (20.0) | 3.429 (1.532–7.674) | 0.003 | ||
| Urinary catheterization | 25 (64.1) | 41 (43.2) | 2.352 (1.089–5.080) | 0.029 | ||
| Gastric catheterization | 19 (48.7) | 22 (23.2) | 3.152 (1.433–6.934) | 0.004 | ||
| Central venous catheterization | 21 (53.8) | 25 (26.3) | 3.267 (1.501–7.110) | 0.003 | ||
| Medical history | ||||||
| IUC stay (previous 1 month) | 19 (48.7) | 27 (28.4) | 2.393 (1.108–5.168) | 0.026 | ||
| Prior surgery (previous 1 month) | 14 (35.9) | 21 (22.1) | 1.973 (0.874–4.454) | 0.102 | ||
| Severity of illness at the time of BSIs | ||||||
| Pitt bacteremia score (median, IQR) | 4 (1, 7) | 1 (1, 3) | 1.583 (1.296–1.933) | < 0.0001 | 1.609 (1.226–2.111) | 0.001 |
| Treatment | ||||||
| Inappropriate empirical treatment after BSIs | 26 (66.7) | 29 (30.5) | 4.552 (2.053–10.091) | < 0.0001 | 6.756 (1.992–23.753) | 0.003 |
| Inappropriate definitive treatment after BSIs | 3 (7.7) | 6 (6.3) | 1.236 (0.293–5.212) | 0.773 | ||
| CRKP infection, n(%) | 23 (59) | 27 (28.4) | 3.620 (1.662–7.885) | 0.001 | ||
Data are expressed as n (%) or median (IQR)
Abbreviations: CCI, Charlson comorbidity index; CRKP, carbapenem-resistant K.pneumoniae; BSIs, bloodstream infections; OR, odds ratio