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. 2024 Aug 21;19:112. doi: 10.1186/s13020-024-00979-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — RNA-seq analysis of PA3264 in 4T1 orthotopic tumors. A The bar chart showed the number of upgraded or downgraded DEGs in tumors between the control and PA3264-treated groups. B Clustering heatmap analysis of DEGs in different groups using RNA-seq analysis. C GO enrichment analysis of the candidate targets of PA3264 in the treatment. The top 10 GO functional categories were selected. D KEGG pathway enrichment of the candidate targets of PA3264 in treating TNBC. The size of the circles represents the number of genes, and the color represents the p-value. E qRT-PCR verification of DEGs related to the PI3K/AKT signaling pathway. Data were presented as mean ± SEM, n = 9, *p < 0.05, **p < 0.01, ***p < 0.001 vs. the control group