Table 1.

Number and density of immunoparticles for GluN1 at different excitatory synapses in the CA1 field, CA3 field and DG at 12 months of age

	CA1 SR		CA1 SLM		CA3 MF	CA3 A/C	DG (PP)
WT	Spines	Interneurons	Spines	Interneurons
Area of IMP clusters (n) (PSD of excitatory synapse)	54	45	34	49	29	15	15
Mean (± SEM) (µm)	0.033 ± 0.002	0.056 ± 0.005	0.033 ± 0.002	0.071 ± 0.005	0.053 ± 0.004	0.038 ± 0.014	0.044 ± 0.007
Median gold particles	11	16	14	19	27	12.5	17
Range	36 − 2	59 − 2	34 − 4	44 − 7	53 − 6	21 − 3	35 − 10
Particles (CV)	0.59	0.68	0.47	0.48	0.47	0.40	0.42
Density gold particles (µm 2 )
Mean (± SEM)	399.82 ± 33.15	356.95 ± 26.24	463.75 ± 32.67	337.91 ± 23.34	522.99 ± 26.52	366.45 ± 57.09	518.66 ± 54.54
Median	336.70	378.00	387.10	335.70	512.12	363.58	513.64
Range	1313 − 104	707.7–38.40	911.9–140.6	776.6-76.23	810.60-232.16	809.76-111.62	1017.20-203.93
Density (CV)	0.60	0.49	0.41	0.48	0.27	0.53	0.38
APP/PS1
Area of IMP clusters (n) (PSD of excitatory synapse)	53	44	48	37	31	15	15
Mean (± SEM) (µm)	0.03 ± 0.02	0.056 ± 0.004	0.036 ± 0.004	0.073 ± 0.010	0.055 ± 0.006	0.034 ± 0.009	0.043 ± 0.005
Median gold particles	12	16	7	8	20	14	5
Range	28 − 2	49 − 1	25 − 1	37 − 1	54 − 2	22 − 6	12 − 1
Particles (CV)	0.52	0.54	0.72	1.1	0.39	0.59	0.58
Density gold particles (µm 2 )
Mean (± SEM)	451.06 ± 28.40	349.60 ± 21.90	237.86 ± 16.58	184.37 ± 20.54	422.10 ± 21.65	397.62 ± 50.68	133.13 ± 19.19
Median	425.90	349.7	236.80	148.30	412.00	363.35	132.44
Range	979.9-78.51	708.9–30.00	545.7-22.72	454.1–9.72	676.00-143.56	715.92-197.67	239.09–20.38
Density (CV)	0.45	0.41	0.48	0.67	0.29	0.46	0,50

A/C, associational/commissural; MF, mossy fibres; PSD, postsynaptic density; PP, perforant pathway; SR, stratum radiatum; SLM, stratum lacunosum-moleculare