Table 2. Classification of genes from microarray.
Genes were grouped based on their biological functions. Notable changes in gene expression are shown in boldface.
| Category of genes | Description | Mouse NGF (fold change) | Sputa NGF (fold change) |
|---|---|---|---|
| Cell cycle | Growth arrest and DNA-damage-inducible 45α | 3.63 | 3.18 |
| Proliferating cell nuclear antigen | −2.07 | −1.74 | |
| ret proto-oncogene | 2.87 | 2.91 | |
| ret proto-oncogene | 4.06 | 4.41 | |
| Cyclin-dependent kinase inhibitor 1A | 4.99 | 4.26 | |
| Growth-associated protein 43 | 2.27 | 2.10 | |
| Apoptosis | Apoptotic death agonist BID | 3.36 | 2.85 |
| Bcl-2-like-1 | 2.22 | 1.77 | |
| Eicosanoid synthesis | Prostaglandins endoperoxide synthase 1 | 4.59 | 2.36 |
| IL-12 p35 subunit | 6.19 | 4.72 | |
| Transcription factors | Core promoter element-binding protein | 2.53 | 1.57 |
| fos-like antigen 1 | 8.57 | 3.51 | |
| Nuclear transcriptional factor-Y-β | 2.01 | 1.14 | |
| ISL1 transcriptional factor, LIM/homeodomain 1 | 2.75 | 1.74 | |
| Global ischaemia-induced protein GIIG15B | −2.38 | −2.07 | |
| DNA polymerase β | 2.20 | 1.88 | |
| GATA-binding protein 4 | 1.39 | 2.17 | |
| Myelin transcription factor 1-like | −2.20 | −1.33 | |
| Signal transducer and activator of transcription 3 | 2.04 | 1.66 | |
| ATF3 | 2.2 | −1.54 | |
| Egr 1 | 15.14 | 12.91 | |
| Translational factors | Eukaryotic initiation factor-5 | 2.03 | 1.60 |
| Eukaryotic initiation factor-2B, subunit 3 | 2.04 | 1.82 | |
| Others | Meprin 1α | 2.55 | 2.10 |
| CE | 11.08 | 8.22 | |
| Mast cell protease 7 | 88.65 | 71.51 | |
| Plysia ras-related homologue A2 | 2.69 | 2.33 | |
| Small GTP-binding protein rab5 | 2.20 | 1.79 | |
| GTP cyclohydrolase 1 | 3.20 | 2.10 | |
| Phospholipase D | 2.41 | 2.55 | |
| Kinesin family member 1B | 1.45 | 2.01 | |
| Procollagen, type XII, α1 | 2.30 | 1.41 | |
| Integrin β1 | 2.31 | 2.39 | |
| Insulin receptor substrate 1 | 2.06 | 1.27 | |
| Double cortin and calcium/CaM-dependent protein kinase-like 1 | 2.69 | 1.84 | |
| Gap junction membrane channel protein β5 | 2.79 | 2.04 | |
| Jun-B oncogene | 2.28 | 2.39 | |
| Opioid receptor-like | 2.13 | 2.73 | |
| Arginine V1a | 5.43 | 20.25 | |
| Purinergic receptor P2X, ligand-gated ion channel 2 | −2.91 | −1.59 | |
| Purinergic receptor P2X, G-protein coupled 2 | 2.06 | 2.11 | |
| Adenosine monophosphate deaminase 3 | 2.48 | 1.85 | |
| Myelin basic protein | 1.04 | 2.35 | |
| Prolactin receptor | 2.17 | 1.54 | |
| Serum-inducible kinase | 7.26 | 3.12 | |
| Syntaxin | 2.71 | 1.45 | |
| Dynamin 1 | −2.07 | −1.39 | |
| Guanosine diphosphate dissociation inhibitor 3 | 2.17 | 2.39 | |
| Annexin 5 | 3.03 | 2.77 | |
| Neural receptor protein-tyrosine kinase | 9.19 | 3.16 | |
| Moesin | 2.97 | 2.48 | |
| Vesicle-associated membrane protein, associated proteins B and C | 1.71 | 2.10 | |
| ADP-ribosylation-like 4 | 2.71 | 2.28 | |
| Solute carrier family 1, member 3 | 6.28 | 4.99 | |
| Solute carrier family 9, member 4 | −1.44 | 2.23 | |
| Syndecan 1 | 2.95 | 2.39 | |
| Myosin IXA | 2.22 | 1.99 | |
| Potassium inwardly rectifying channel, subfamily J, member 6 | 2.20 | 1.95 | |
| Protein kinase, cAMP-dependent regulatory, type I, α | 2.53 | 2.08 | |
| Coated vesicle membrane protein | 2.00 | 1.89 | |
| Regulator of G-protein signalling protein 2 | 2.25 | 1.38 | |
| Cold-inducible RNA-binding protein | 1.97 | 2.30 | |
| Microtubule-associated protein 1b | 2.31 | 1.29 | |
| Acid phosphatase 5 | 2.01 | 1.91 | |
| Profilin II | 2.38 | 2.06 | |
| Glutamate receptor, ionotrophic, NMDA2C | −2.50 | −1.91 | |
| Lysosomal membrane glycoprotein 2 | −1.97 | −2.20 | |
| NGF receptor-associated protein | −2.03 | −1.55 | |
| Calcium-related pathway | Very-low-density lipoprotein receptor | 2.16 | 1.83 |
| Very-low-density lipoprotein receptor | 2.57 | 2.00 | |
| Very-low-density lipoprotein receptor | 2.22 | 2.10 | |
| Calcium-binding protein p22 | 3.66 | 2.19 | |
| S-100-related protein, clone 42C | 3.36 | 2.71 | |
| S-100-related protein A4 | 2.06 | 1.95 | |
| Cadherin | −3.14 | −2.33 | |
| Calcium channel, voltage-dependent, T-type, αII subunit | 5.54 | 7.21 | |
| Protein phosphatase 3, regulatory subunit B, α isoform, type 1 | 2.23 | 1.78 |