Figure 3.

¹⁸F-fluciclovine kinetics in the different adipose tissue depots using PET imaging

(A and B) PET time-activity curves over the 24 min of acquisition after ¹⁸F-fluciclovine injection in (A) blood pool in the ascending aorta (as input function) and sternocleidomastoid muscle as reference tissue as well as (B) in the adipose tissue depots of interest (n = 35). Each time point represents a mid-frame value. Data are means ± SEM.

(C) Tracer delivery rate (K₁: index of tissue perfusion) in the different adipose tissue depots (n = 35).

(D) Net uptake rate (K_i) for ¹⁸F-fluciclovine in the different adipose tissue depots (n = 35).

(E) Flux rate from interstitial to intracellular compartment (k3) for ¹⁸F-fluciclovine in the different adipose tissue depots (n = 35). Parametric analysis was not performed for one participant due to lack of imaging data for the first 4 min after injection. Data are median and interquartile range. p values were determined by using the Friedman test with Dunn correction for multiple comparisons. ABD, abdominal; SCM, sternocleidomastoid muscle; SCV, supraclavicular; UCH, upper chest; PET, positron emission tomography. ∗p < 0.05, ∗∗∗p < 0.001, and ∗∗∗∗p < 0.0001. Related also to Figures S1–S3.