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. 2024 Aug 21;13(1):2393442. doi: 10.1080/2162402X.2024.2393442

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 5. — M1 macrophage -secreted factors suppress the expression of AR target genes. (a) AR and (b) PSA (KLK3) expression after pre-treatment with R1881 followed by control (ctrl), M0 or M1 CM exposure. (c) Heatmap showing DEGs related to androgen response (ANDROGEN_NELSON_UP gene set) in control (ctrl), M0, M1 or M2 CM treatment. p <0.01, |logFC|>0.5, transcripts per million (TPM)>1.05. The data represents mean ± SD. Statistical significances were tested with the Kruskal–Wallis nonparametric test. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.