Figure 3.

Anoikis resistance mechanism and targeted drugs in glioma. In this image, we elucidate the intricate anoikis-resistance pathways operative in glioma, along with their consequential clinical implications. Anoikis, which is inherently designed to eliminate impaired cells, is crucial for maintaining cellular equilibrium within the microenvironment. However, in gliomas, a disrupted resistance to anoikis emerges, enabling cancerous cells to evade this regulatory process and disrupting the natural course of malignant cell clearance.