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. 2024 Aug 9;14:1397863. doi: 10.3389/fonc.2024.1397863

Table 4.

A summary of small molecule inhibitors targeting key components of RCD.

Inhibitor Process of inhibition Illustrate
Bcl-2 family inhibitors Apoptosis ABT-199(Venetoclax)
Caspase inhibitor Apoptosis Z-VAD-FMK
RIPK1 inhibitor Necroptosis Necrostatin-1(Nec-1)
RIPK3 inhibitor Necroptosis GSK’872
Caspase-1 inhibitor Pyroptosis VX-765
Gasdermin D inhibitor Pyroptosis Under research
PI3K/mTOR inhibitor Autophagy Rapamycin
VPS34 inhibitor Autophagy 3-Methyladenine(3-MA)
Iron chelating agent Ferroptosis Deferoxamine (DFO)
Copper chelating agent Cuproptosis D-Penicillamine
HSP90 inhibitor Anoikis NVP-AUY922
PARP inhibitor ICD Olaparib