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. 2004 Dec 7;384(Pt 3):591–598. doi: 10.1042/BJ20040380

Figure 4. GGOH, and not FOH, reverses ZOL-mediated BSP up-regulation in Saos-2 cells.

Figure 4

(A) Saos-2 cells were cultured with ZOL (20 μM) in the presence or absence of FOH (20 μM) for 48 h. (B) Saos-2 cells were cultured with ZOL (20 μM) in the presence or absence of GGOH (20 μM) for 48 h. Steady-state levels of BSP mRNA were analysed using real-time RT–PCR and normalized for variations in GAPDH mRNA levels. The expression of BSP mRNA is given as fold-induction relative to untreated control cells (cont). Experiments were performed three times with comparable results. *P<0.005 and **P<0.0001 represent significant difference compared with ZOL-treated cells.