Table 1. Relative permeability rates of antibiotics through Omp38 porins.
Permeability rates of antibiotics were calculated relative to the rate of L-arabinose (Mr 150), which was set to 100%.Values given as mean values±S.D. are obtained from three independent assays, and liposomes with BSA and liposomes without any protein were used as negative controls.
| Permeability rate (%) | |||
|---|---|---|---|
| Antibiotic | Mr | Native BpsOmp38 | Refolded BpsOmp38 |
| Amikacin | 782 | 0 | 0 |
| Gentamicin | 709 | 0 | 0 |
| Ceftazidime | 637 | <1 | <1 |
| Cefepime | 572 | 4±1.6 | 5±0.5 |
| Clindamycin | 505 | 8±0.9 | 8±0.5 |
| Ciprofloxacin | 421 | 15±0.9 | 15±0.9 |
| Meropenem | 383 | 20±0.5 | 20±0.5 |