Table 2.
Demographic and clinical characteristics of cohort according to Lille score cutoff of < 0.45 and ≥ 0.45 at day 4 and 7
| Contents | Lille score < 0.45 | Lille score ≥ 0.45 | ||||
|---|---|---|---|---|---|---|
| Day 4 | Day 7 | Combined | Day 4 | Day 7 | Combined | |
| No. of subjects | 29 | 89 | 118 | 18 | 65 | 83 |
| Age in yearsa | 42.5 (9.28) | 42.5 (10.0) | 43.0 (10.2) |
53.4 (12.1) |
48.1 (11.2) |
49.2 (11.6) |
| Female/Male | 15/14 | 46/43 | 61/57 | 9/9 | 35/30 | 44/39 |
| Race (AA/W/unknown) | 3/23/3 | 15/64/10 | 18/87/13 | 3/12/3 | 9/52/4 | 12/64/7 |
| Ethnicity % non-Hispanic | 88.46% | 88.37% | 88.4% | 88.88% | 96.92% | 95.18% |
| Weight in kg |
84.1 (20.2) |
81.9 (23.2) |
82.8 (22.3) |
81.2 (23.4) |
90.1 (27.8) |
88.2 (27.0) |
| BMI kg/m2 |
29.2 (7.28) |
28.2 (6.78) |
28.6 (6.81) |
37.4 (39.8) |
30.5 (8.40) |
32.0 (19.8) |
| Obesity (BMI ≥ 30 kg/m2) |
18.18% (8) |
21.85% (33) |
22.38% (41) |
15.90% (7) |
19.86% (30) |
18.40% (37) |
| Type 2 diabetes mellitus |
9.09% (4) |
8.60% (13) |
8.95% (17) |
9.09% (4) |
7.28% (11) |
7.46% (15) |
| MetALD |
22.72% (10) |
28.47% (43) |
28.3% (53) |
15.90% (7) |
21.85% (33) |
19.9% (40) |
| AST U/L |
187 (120) |
243 (222) |
226 (200) |
183 (77.2) |
203 (108) |
199 (102) |
| ALT U/L |
69 (76.3) |
58.5 (43.3) |
60.2 (51.7) |
63.4 (41.1) |
57.7 (34.2) |
58.9 (35.6) |
| Total bilirubin mg/dL |
14.2 (10.1) |
17.2 (10.2) |
16.2 (10.4) |
23.5 (12.9) |
21.1 (11.7) |
21.7 (11.9) |
| Albumin g/dL |
2.79 (0.476) |
2.76 (0.523) |
2.79 (0.532) |
2.65 (0.695) |
2.48 (0.422) |
2.51 (0.494) |
| PT sec |
20.5 (3.25) |
21.3 (5.66) |
20.9 (5.25) |
22.8 (5.61) |
24.8 (6.40) |
24.4 (6.26) |
| INR |
1.78 (0.363) |
1.85 (0.640) |
1.81 (0.588) |
2.03 (0.578) |
2.26 (0.777) |
2.21 (0.741) |
| Creatinine mg/dL |
0.753 (0.415) |
0.968 (0.632) |
0.927 (0.584) |
1.07 (0.478) |
1.39 (1.02) |
1.32 (0.934) |
| DF (using PT 13.5) |
46.6 (19.5) |
52.9 (27.4) |
50.2 (26.9) (19.5) |
66.5 (32.2) |
73.2 (31.8) |
71.7 (31.8) |
| MELD (admission) |
21.7 (5.74) |
22.5 (7.35) |
22.1 (7.03) |
27.2 (5.95) |
28.3 (7.58) |
28.1 (7.24) |
| MELD (discharge) |
30.0 (39.3) |
23.4 (5.62) |
24.8 (19.7) |
27.8 (7.99) |
28.8 (6.31) |
28.6 (6.67) |
AA African American, W white, BMI body mass index, MetALD metabolic dysfunction associated alcoholic liver disease, AST aspartate aminotransferase, ALT alanine aminotransferase, PT prothrombin time, INR international normalized ratio, MDF maddrey discriminatory function, MELD model for end stage liver disease
aData presented as number (n), mean (± SD), or %