Table 2.
Multivariable cox-regression analysis of factors associated with OS and PFS
| OS | |||
| Variable | Hazard Ratio | (95% Confidence Interval) | P value |
| Age | 1.02 | 1.02–1.03 | < 0.001 |
| Performance status 1* | 1.20 | 0.99–1.43 | 0.0575 |
| Performance status 2 | 1.07 | 0.84–1.37 | 0.5795 |
| Performance status 3 | 1.16 | 0.75–1.80 | 0.5125 |
| Performance status 4 | 1.08 | 0.74–1.57 | 0.6686 |
| Extent of resection- GTR vs Biopsy | 0.50 | 0.39–0.64 | < 0.001 |
| Extent of resection- STR vs Biopsy | 0.76 | 0.63–0.92 | 0.0052 |
| Completed full STUPP protocol | 0.52 | 0.41–0.67 | < 0.001 |
| Time spent compliant with NICE imaging recommendations** | 0.56 | 0.46–0.66 | < 0.001 |
| Time spent compliant with EANO imaging recommendations*** | 0.54 | 0.45–0.63 | < 0.001 |
| PFS | |||
| Variable | Hazard Ratio | (95% Confidence Interval) | P value |
| Age | 1.02 | 1.01–1.02 | < 0.001 |
| Performance status 1* | 1.07 | 0.89–1.28 | 0.467 |
| Performance status 2 | 0.88 | 0.69–1.12 | 0.307 |
| Performance status 3 | 0.84 | 0.54–1.30 | 0.438 |
| Performance status 4 | 0.94 | 1.18–1.87 | 0.738 |
| Extent of resection- GTR vs Biopsy | 0.52 | 0.42–0.67 | < 0.001 |
| Extent of resection- STR vs Biopsy | 0.67 | 0.55–0.82 | < 0.001 |
| Completed full STUPP protocol | 0.67 | 0.53–0.83 | < 0.001 |
| Time spent compliant with NICE imaging recommendations** | 0.93 | 0.79–1.10 | 0.349 |
| Time spent compliant with EANO imaging recommendations*** | 0.99 | 0.84–1.16 | 0.874 |
*Compared to performance status 0 as reference variable. * Time varying covariate. ** Time varying covariate, different model to presented in table