Fig. 4. Sixty LY1 jelly roll domains form the core of anellovirus particles.

A The LY1 core structure comprised of 60 jelly roll domains pack in icosahedral symmetry with one domain uniquely colored in red. B Two jelly roll domains are shown in red with the observed C-terminal domain backbone colored in cyan. The jelly roll domains are arbitrarily labeled JR¹ and JR² with the first (K48) and last (V562) observed residues for each protomer labeled with the corresponding number for clarity. C A single jelly roll domain is oriented to show the β-sheet on the interior of the particle core. Sidechains of basic residues in position to contact with the viral genome are shown and labeled. D The sequence of LY1 is shown for the ARM, jelly roll, and C-terminal regions. Basic residues of LY1 positioned to potentially contact the viral genome and shown in (C) are indicated with asterisks above the sequence along with the secondary structure elements.